Cleanance Comedomed anti-blemish concentrate

Reduces excess sebum - Reduces imperfections - Tightens pores

Cleanance Comedomed, an innovation from the Laboratoires Eau Thermale Avène, to fight the appearance of spots and prevent them from reappearing, with clinically proven effectiveness from seven days*. High tolerance for acne-prone skin.

  • Action rapide
  • Anti-récidive***
  • High tolerance
  • Sans parfum

Effectiveness demonstrated within 7 days*.

Pump bottle

Usable by Pregnant women - Young mothers - Teenagers - Adults

Age From 12 year(s)

Skin type Acne-prone skin

Need Anti-imperfections - Anti recurrence

Made in France


Helping you get rid of blemishes once and for all

Frequency of use

2 times a day

Tips for use

Dispense 1 dose of Cleanance Comedomed on your fingertips.
• Start by dabbing it onto the T-zone and the cheeks.
• Use circular motions to boost penetration.
• Finish by smoothing on the cheeks and lower face.
Reapply morning and evening.

An expert tip

The 2 essential steps to take care of your oily, acne-prone skin!
Our one piece of advice:
• Rigorously yet gently remove make-up and cleanse the face, both morning and evening!
• Also apply an anti-blemish product morning and evening.

Clinical results

Effective for every oily,acne-prone skin type

7 daysreduces spots within 7 days¹
90%prevents recurrence for 90%²
45%reduced imperfections by -45% as of 2 months³, significant result versus control group

¹Tolerance and efficacy study under dermatological control on 51 subjects, use of Cleanance Comedomed twice a day for 56 days.
²International observational clinical study, 90% of patients without acne relapse at T6 months, (according to the definition of relapse in the protocol GEA≥3 requiring the introduction of an oral or local drug treatment), 48 subjects, 2 applications per day of Cleanance Comedomed alone for 6 months.
³36 subjects with slight to moderate imperfections. Comparative clinical study (group treated twice/day N=18), control group (N=18) for 56 days.

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Your simple and effective routine to get rid of blemishes, spots, and blackheads.


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Your reviews on  Cleanance Comedomed anti-blemish concentrate

Your reviews on Cleanance Comedomed anti-blemish concentrate

Tell us what you think, your opinion is very important for us.


would recommend this product to a friend

Opinion 1 on 3265
Waiting for results

Waiting for results

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Love Avene!

I love the mix of the products in this kit. I've been using Avene products for many years now and I cannot live without the Cleansing Cream. It is the best for my skin. I love the small size of the thermal water because I can easily pack it in my purse when I travel and when we hike.

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The serum is very good.

The serum is very good.

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Love it

Fresh light clean scent.

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My favorite Avene product

Love it! I have been using this since Covid started in 2020. In combination with gentle exfoliation and witch hazel, this has saved my skin. Major breakouts are now just minor spot treatments.

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Ingredients Ingredients

A combination of innovative active ingredients selected for their effectiveness on sensitive oily,acne-prone skin.


The consumer is advised to systematically check the composition of the product before purchasing it.



Plant-based active ingredient with patented properties from Pierre Fabre Research. Milk thistle extract acts at the source of micro-blemishes and visibly reduces their appearance. Fragrance-free, alcohol-free. The smell of the product is due to the strong presence of the active ingredient Comedoclastin™ in the product. The smell evaporates upon application, without irritating the skin.

Avene thermal water


Thanks to a unique mineral and biological characteristic, it has soothing, repairing and rebalancing properties.


Any concerns or questions? Our experts are here for you.

Rest assured, Cleanance Comedomed does not contain any.

The smell is linked to the active ingredient Comedoclastin™ (milk thistle extract), which is present in the product at a dosage of 25%. This odour evaporates quickly and does not interfere with the tolerance of the product and does not present any risk to the skin. It has been proven that skin tolerates Cleanance Comedomed extremely well.

Yes, the start of an active treatment (whether a drug or dermo-cosmetic) can act as a trigger for a breakout. Under its effect, a large number of spots, previously dormant under the skin, emerge at the same time. This causes the phenomenon of a "flare-up" (an explosion or exacerbation of pimples). Treatment should be continued in all cases, because the next phase will allow for the rapid exhaustion of the "embryo stock” of spots.This will help to keep blemishes to a minimum.
In case of discomfort, use can be reduced to once a day.

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