Cicalfate+ Restorative Protective Cream

Avène’s restoration essential

From a simple graze to a superficial cut, superficial burn, the effects of cold or sun, and even the side effects of dermatological procedures or anti-cancer treatments, the skin undergoes an alteration of its barrier. It becomes sensitive and weakened, and therefore more vulnerable to external aggressions. If not properly cared for, this alteration can eventually leave lasting scar marks.​


With the Cicalfate+ range, we offer restorative care that meets all your restoration needs. At the heart of this dermatologist-prescribed range*, the proven Restorative and Protective Cream: restoration in 48 hours¹ and 48 indications of use².​


¹Promotes epidermal repair from 48h. Clinical study under dermatological, pediatric and gynecological control, 248 subjects, 2 applications per day for 21 days, clinical scoring at 48h.
²See the list of use cases mentioned below
*Source GERS – SOG EARLY FRANCE – Sales on prescription in pharmacies and parapharmacies – dermo-cosmetic market definition established by Pierre Fabre DCPC laboratories – Skin repair care market. Rolling October 2025 data in volume.

av_cicalfate-_repairing-protective-cream

45 INDICATIONS OF USE*

Rediscover the Restorative reflex for your skin problems

  • <h3 style= "color: black;">Everyday irritations</h3>

    Everyday irritations

    - Perioral discomfort

    - Post-shaving discomfort

    - Insect bites after scratching

    - Superficial burns

    - Redness in the baby’s diaper area

    - Eyelid discomfort

    - Discomfort around the eyes

    - Sun-related discomfort, superficial sun erythema

    - Cold-induced discomfort

    - Superficial cuts

    - Scratches without bleeding, grazes, abrasions

    - Claw marks / scratch marks

    - Post-inflammatory scabs

    - Localized discomfort on the face, hands, feet or body

    - Sensitive scalp

  • <h3 style= "color: black;">Superficial aesthetic procedures</h3>

    Superficial aesthetic procedures

    - Post-superficial peeling

    - Post-cryotherapy

    - Post-laser hair removal

    - Discomfort after electrical hair removal

    - Post-laser acne marks

    - Post-laser rosacea treatment

    - Post-superficial pigment laser

    - After discomfort caused by waxing

  • <h3 style= "color: black;">Post-procedures</h3>

    Post-procedures

    - Superficial dermabrasion

    - Post-blepharoplasty¹

    - Post-electrocoagulation

    - Post-operative scar after re-epidermization

    - Post-tattoo²

    ¹ After re-epidermization and removal of stitches.
    ² After re-epidermization, at least 4 days later.

  • <h3 style= "color: black;">Oncology<h3>

    Oncology

    - As support during radiotherapy to manage grade‑1 radiodermatitis

    - Hand‑foot syndrome, grade 1

    - Following treatments: chemotherapy, hormone therapy, targeted therapies, and immunotherapy

  • <h3 style= "color: black;">Treatments association</h3>

    Treatments association

    Irritated skin following drug treatments: post-acne, post-rosacea, etc...

  • <h3 style= "color: black;">Supportive skin solutions</h3>

    Supportive skin solutions

    - Contact irritation

    - Hand‑foot‑mouth irritation

    - Skin prone to atopic eczema

    - Excoriated acne lesions

    - Childhood skin rash

    - Diaper rash related to incontinence

  • <h3 style= "color: black;">Intimate area irritations</h3>

    Intimate area irritations

    Irritations of the external intimate areas.

  • <h3 style= "color: black;">Severe irritations</h3>

    Severe irritations

    - Cracks / fissures

    - Itching related to skin dryness

    - Localized dryness on the face

    - Nipple irritation

    RESULTS

    Significant, clinically proven effectiveness on complex irritations

    1. 48 hours

      Restores the skin in 48 hours¹

    2. 90%

      less visible marks²

    3. 2.5x

      [C+-Restore]™ restores the skin barrier 2.5 times more effectively³

    4. 4000

      Proven effectiveness in over 4,000 patients⁴

    ¹Promotes epidermal restores after 48 hours. Clinical study under dermatological, paediatric and gynaecological control, 248 subjects, 2 applications per day for 21 days, clinical evaluation at 48 hours.2244 patients, % satisfaction, 2 applications per day for 21 days.³In-vitro test, [C+-Restore]™ versus untreated, on keratinocyte migration at 24 hours.

    ⁴244 patients, % satisfaction, 2 applications per day for 21 days.

    av_cicalfate-_repairing-protective-cream

    A FEW WORDS FROM OUR EXPERT

    The Cicalfate+ range not only helps to relieve irritation, but also speeds up healing thanks to research carried out by our Laboratories into the active role of the "good" bacteria present in Avène thermal spring water.

    ELODIE

    Avène Team

    A UNIQUE TRIO OF ACTIVE INGREDIENTS

    Helping to restore your skin

    • AV_cicalfate-_active-ingredient_C-RESTORE_STILL_1_1

      [C+-Restore]™

      Patented postbiotic active ingredient derived from
      Avène Thermal Spring Water. Promotes epidermal restore.

    • AV_CICALFATE-_LANDING_PAGE_MATERIALS

      Copper-Zinc Complex

      Antibacterial complex, limits the risk of bacterial proliferation.

    • AV_EAU-THERMALE_Representation-Eau_png

      Avène Thermal Spring Water

      Provides all its soothing, microbiome-rebalancing and strengthening properties.
       

      Cicalfate+ Restorative Protective Cream

      A MULTI-USE RESTORATIVE SOLUTION FOR FRAGILIZED SKIN

      • Restorative and purifying active ingredients
      • Immediately soothes discomfort
      • Promotes the skin restoration from 48 hours

      Discover Cicalfate+ Restorative Protective Cream

      Cicalfate+ Intense Skin Recovery Serum

      A DUAL RESTORING AND SOOTHING EFFECT

      • Restores the skin barrier in 1 day*
      • Skin is hydrated for 24 hours**

      The 1st Cicalfate+ face serum, to be used as the first step in your routine or as a monthly restore treatment, along with your usual day cream. 

      *Assessment of skin barrier restore after detergent damage on human skin samples.  **IH kinetics, single application on 32 subjects.

      Discover the Cicalfate+ serum

      Discover the Cicalfate+ range

      For every irritated skin type, there is a Cicalfate+ solution

      • Absorbing soothing spray

        Cicalfate

        Absorbing soothing spray
        Restores - Dries - Purifies

      • Hydrating skin recovery emulsion

        Cicalfate

        Hydrating skin recovery emulsion
        Soothes - Hydrates - Restores

      • Purifying cleansing gel

        Cicalfate

        Purifying cleansing gel
        Soothes - Purifies - Cleanses - Gently washes

      • Scar gel

        Cicalfate

        Scar gel
        Soothes - Reduces the appearance of scars

      • Cicalfate+ Lips Repair lip balm

        Cicalfate

        Cicalfate+ Lips Repair lip balm
        Nourishes - Protects - Restores

        IT’S ALL ABOUT YOU

        All the information and useful advice you need to take care of your skin every day.

          FREQUENTLY ASKED QUESTIONS

          The Cicalfate+ range (Cream, Spray and Gel) offers a wide range of restoring care products for all sensitive and fragilized skin: scratches, minor injuries, superficial burns, post-dermatological procedures, nappy rash, etc. 
          The products in the Cicalfate+ range promote skin restoration, dry out moist areas, improve the appearance of scars and immediately soothe. 
          With its proven effectiveness, Cicalfate+ is the top restoring range prescribed in Europe.

          Cicalfate+ can be used for baby care, for example:
          • Cicalfate+ Cream is recommended for soothing the baby's bottom and promoting restoration in case of nappy rash.
          • Cicalfate+ Spray is recommended for soothing and drying out skin rashes (chickenpox). It is not a substitute for an antiseptic.

          Cicalfate+ Cream can be applied to the skin as well as to the external intimate areas: the vulva, labia, anus.
          Cicalfate+ Cream can be prescribed in particular to soothe and promote skin restoration in the event of superficial burns/intimate irritations.

          We recommend the use of Cleanance Comedomed to treat acne-prone and oily skin.
          Cicalfate+ Cream can be used to prevent the appearance of dark marks left behind by acne. Consider applying it after scratching or picking at a spot.