Comedoclastin™
The plant-based active ingredient with patented properties, extracted from Milk Thistle, acts on the micro-comedones at the root of blemishes and limits the reapperance of new spots.
Cleanance
Comedomed Anti-blemish concentrate
Permanent Reduces the appearance of imperfections - Tightens pores - Removes excess sebum
Cleanance Comedomed Concentrate, our best global solution for acne-prone skin that targets imperfections at the root, offering a durable effect with clinically proven results from seven days*. Highly tolerant for acne-prone skin. Safe for use by pregnant women.
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Effectiveness demonstrated within 1 week*.
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Fast-acting, durable efficacy***, high tolerance
Usable by Pregnant women - Young mothers - Teenagers - Adults
Age From 12 year(s)
Skin type Acne-prone skin
Need Anti-imperfections - Anti recurrence
Made in France
Cleanance Comedomed Anti-blemish concentrate is our most advanced solution for acne-prone skin, whether it's sudden or even hormonal acne pimples, developed by Avène Dermatological Laboratories.
Powered by 25% of our patented active ingredient ComedoclastinTM**, extracted from Milk Thistle seeds, this solution targets imperfections at the root as they form and offer long-lasting results.
Clinically proven to reduce spots in seven days*, Cleanance Comedomed offers a durable action, with consistent use, up to one year***. Designed for oily skin, it is suitable for adults and teenagers from 12 years old. Its fluid, non-greasy texture ensures quick absorption, leaving the skin mattified.
Usable alone, in combination, or as a follow-up to acne medication, this non-comedogenic care guarantees high tolerance for sensitive skin. Safe for use by pregnant women.
Benefit
The revolutionary solution for acne-prone skin that reduces the appearance of spots within seven days* and provides a durable efficacy thanks to Comedoclastin™, a plant-based key ingredient extracted from Milk Thistle, with patented properties**.
Benefits
• EFFECTIVE: Effective on all types of imperfections of acne-prone skin (including inflammatory, blackheads, papules, pustules, etc.), thanks to its high concentration of 25% of our patented active ingredient: Comedoclastin™**, which acts at the root of imperfections to reduce and provide a long-lasting effect.
• FAST: Reduces the appearance of spots in as little as 1 week*. Offers a long-lasting efficacy***. For clearer skin and better comfort daily.
• HIGH TOLERANCE: Used alone or in combination with medical treatments, its tolerance by sensitive, acne-prone skin is clinically demonstrated*.
• SAFE: Safe for use by pregnant women.
*Used twice a day on the face, it offers a long-lasting effect on the appearance of blemishes. Efficacy demonstrated over 8 weeks, 37 subjects.
* Tolerance and efficacy study under dermatological control on 51 subjects, use of Cleanance Comedomed twice a day for 56 days.
** Patent registered.
*** Clinical study proving that the product povided a lasting efficacy for 85% of subjects from 1 year with 2 applications a day on the face, 54 subjects.
**IQVIA - Xponent PharmaOne - Acne market (83A1A) in pharmacies in France - Year 2021 - volume & value.
***Clinical scoring, twice a day on the face, 51 subjects.
*****International observational clinical study, 85% of patients without relapse at 1 year (according to the GEA >3 protocol definition of relapse requiring the introduction of a medicinal treatment – oral or local), 54 subjects, 2 applications per day of Cleanance Comedomed for 1 year.
**IQVIA - Xponent PharmaOne - Acne market (83A1A) in pharmacies in France - Year 2021 - volume & value.
***Clinical scoring, twice a day on the face, 51 subjects.
*****International observational clinical study, 85% of patients without relapse at 1 year (according to the definition of relapse in the GEA >3 protocol requiring the introduction of a medicinal treatment - oral or local), 54 subjects, 2 applications per day of Cleanance Comedomed for 1 year.
Application
Frequency of use
2 times a day
Advice for use:
Spread 1 dose of Cleanance Comedomed on your fingertips, on a cleansed face.
• Start by dabbing it onto the T-zone and the cheeks.
• Use circular motions to boost penetration.
• Finish by smoothing on the cheeks and lower face.
Reapply morning and evening.
An expert tip:
Just one piece of advice: adopt a short but essential routine!
• 1 rigorous careful cleanse of the face or makeup removal: morning and evening!!!
• 1 anti-imperfection treatment: also morning and evening.
Ingredients
AVENE THERMAL SPRING WATER (AVENE AQUA). ISOPROPYL ALCOHOL. PEG-6. GLYCERIN. SILYBUM MARIANUM FRUIT EXTRACT. SILICA. POLYACRYLATE-13. POLYISOBUTENE. POLYSORBATE 20. SORBITAN ISOSTEARATE. WATER (AQUA)
The consumer is advised to systematically check the composition of the product before purchasing it.
Avene thermal water
Thanks to a unique mineral and biological signature, it is known for soothing, strengthening and rebalancing the skin.
Results
• Reduces the appearance of spots within 1 week¹
• Long-lasting efficacy for 90%²
• Reduced the appearance of imperfections by -45% as of 2 months³, significant result versus control group
¹ Tolerance and efficacy study under dermatological control on 51 subjects, use of Cleanance Comedomed twice a day for 56 days.
² International observational clinical study, 90% of patients without relapse at T6 months, (according to the definition of relapse in the protocol GEA≥3 requiring the introduction of an oral or local drug treatment), 48 subjects, 2 applications per day of Cleanance Comedomed alone for 6 months.
³ 36 subjects with slight to moderate imperfections. Comparative clinical study (group treated twice/day N=18), control group (N=18) for 56 days.
² International observational clinical study, 90% of patients without relapse at T6 months, (according to the definition of relapse in the protocol GEA≥3 requiring the introduction of an oral or local drug treatment), 48 subjects, 2 applications per day of Cleanance Comedomed alone for 6 months.
³ 36 subjects with slight to moderate imperfections. Comparative clinical study (group treated twice/day N=18), control group (N=18) for 56 days.
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