Discover the first post-biotic restoring active ingredient derived from Avène thermal spring water: its origin, its uniqueness and its properties.
[C+-Restore]™ is the first patented* post-biotic restoring active ingredient from Avène Thermal Spring Water. Developed from a unique bacterium, it substantially promotes skin renewal.
The development of this promising new active ingredient is revolutionising the traditional approach to skin restoration.
Origin: biotechnological
Source: France
Patent: Patented* active ingredient
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[C+-Restore]™: a next-generation active ingredient 

Recent research has shown the importance of the microbiome in the health of our bodies... and our skin.

There is a unique bacterium in Avène thermal spring water which only survives in the deep, crystalline waters of Avène: Aquaphilus dolomiae. It is from a culture of this precious bacterium that the researchers of Avène Dermatological Laboratories have managed to extract [C+-Restore]™, the 1st post-biotic restoring active ingredient derived from Avène Thermal Spring Water. 

A new active ingredient, drawn from the sources of nature, which promotes the repair of the epidermis

The latest scientific findings on the fundamental role of the microbiome in skin health have led to some exciting innovations in skin repair. And above all, to an increase in efficiency!

The proven power of good bacteria!

What is the definition of the microbiome? Simply put, the microbiome is the set of bacteria that play a positive role in your body.

These "good bacteria" secrete molecules capable of stimulating repair in the intestine. Our researchers have transposed this model of optimal repair to the skin. 

They were able to identify a unique bacterium, specific to Avène thermal spring water: Aquaphilus dolomiae. It is rich in proteins capable of stimulating skin renewal. 

They managed to isolate these molecules. It is from this complex biotechnological process that [C+-Restore]™, a post-biotic active ingredient dedicated to skin repair, was born.

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In practical terms, how does [C+-Restore]™ act?

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By accelerating the natural repair mechanism

Until now, the approach to skin repair has been essentially mechanical: to protect the incomfort with a bandage effect and to attract growth factors around it to accelerate repair.

Now, [C+-Restore]™ helps to restart the skin's natural repair mechanisms. This post-biotic active ingredient accelerates the migration of the cells involved in skin renewal (the keratinocytes). The result? Skin restores faster.


Restores and soothe sensitive fragilized skin.

Everyday boo-boos are a part of our lives, for both young and old alike. And while our skin has the amazing capacity to repair itself naturally, there is no question of leaving it to fend for itself!

Cicalfate+ is THE range to promote skin restoration for the sensitive and fragilized skin of the whole family, even on external intimate areas.

Combined with the purifying Copper-Zinc complex and Avène Thermal Spring Water, the new post-biotic active ingredient [C+-Restore]™ is a key element in the composition of Cicalfate+ products.

A unique formula to immediately soothe and restore your skin within 48 hours(1).

In the same range


[C+-Restore]™: an innovative active ingredient at the heart of the Cicalfate+ range.

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Cicalfate+ Restorative protective cream

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Soothes - Restores - Purifies

Cicalfate+ Absorbing soothing spray

Cicalfate+ Absorbing soothing spray

Restores - Dries - Purifies

Cicalfate+ Scar gel

Cicalfate+ Scar gel

Soothes - Reduces the appearance of scars

The essentials for everyday boo-boos!

The essentials for everyday boo-boos!

Irritation, scratches, redness, scars? For every fragilized skin type, there is a Cicalfate+ solution. Discover the range adapted to the specific needs of each sensitive and fragilized skin type.



The ingredients in our products are carefully selected for their effectiveness.

Avène Thermal Spring Water

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Thanks to its unique mineral and organic signature, it has softening soothing, and restoring properties.

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Patented post-biotic active ingredient* from Avène Thermal Spring Water. Instant ultra-calming effect on all skin sensations.


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Patented post-biotic active ingredient* from Avène Thermal Spring Water.

Anti-itching, helps with redness and inconforts, but also helpsstimulating the skin's defenses.

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*Patent pending

(1) Average time for itching to disappear. Phase IV study on 1,711 patients (France, French overseas territories, Italy). For 75% of patients, use of XeraCalm A.D alone once or twice a day for 7 days in the pruritic xerosis indication.

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